ABSTRACT
Statement of the Problem: Lichen planus is a mucocutaneous disease that is relatively common in middle aged individuals. Some studies have shown that oral lichen planus has a potential to progress to squamous cell carcinoma.p21 is a cyclin-dependent kinase inhibitor that regulates the cell cycle, thus it acts as an inhibitor in cell proliferation
Purpose: This study was aimed to evaluate and compare the immunostaining of p21 [as a proliferation inhibitory factor] in oral lichen planus [OLP] and oral squamous cell carcinoma [OSCC]
Materials and Method: In this descriptive cross-sectional study, p21expression was investigated in 24 samples of oral lichen planus [OLP], 24 samples of oral squamous cell carcinoma [OSCC] and 24 samples of oral epithelial hyperplasia [OEH] by employing immunohistochemical staining
Results: The mean percentage of p21-positive cells in OSCC [54.5 +/- 6.6] was significantly higher than that in OLP [32.8 +/- 6.08] and OEH [9.4 +/- 3.8]. Moreover, OLP samples expressed p21 significantly higher than the OEH. Kruskal Wallis test revealed a statistically significant difference between the groups regarding the intensity of staining [p< 0.001]
Conclusion: According to the findings of this study, the expression of p21 might be related to the potential carcinogenic transformation of lichen planus to SCC. Therefore, continuous follow-up periods for OLP are recommended for diagnosis of the malignant transformations in early stages
ABSTRACT
Keratoacanthoma [KA] is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma [SCC]. Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically. This article aims to illustrate and explicate some of these complicated issues by presenting two cases of KA and a relevant review of literature. It also targets the clinical, histopathologic, and immuno-histochemical features of these two cases. Both presented lesions of this study had appeared on the vermilion border of the lower lip and no vascular or perineural invasion was observed. The results of the immuno-histochemical survey, particularly in staining with marker CD30, confirmed the differential diagnosis of keratoacanthoma from keratoacanthoma-like pseudocarcinomatous proliferations which was consequent to the CD30[+] lymphoid infiltration. Histopathological and immunohistochemical investigation is necessary to disprove the invasive biologic behavior of keratoacanthoma and also to refute all conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia
ABSTRACT
Statement of the Problem: Odontogenic cysts and tumors are the most frequent osseous destructive lesions of the jaws; however, there is little information regarding the relative frequency of these lesions among the Iranian population
Purpose: The purpose of this study was to determine the distribution of clinically and histologically- diagnosed odontogenic cysts and tumors during a period of 13 years in Hamadan, and also its correlation with age, gender, and the site of the lesion
Materials and Method: A descriptive cross-sectional study was performed on 413 oral and maxillofacial specimens during 1996 to 2008.The age and the gender of patients, as well as the site of lesion were recorded. The data were analyzed using SPSS software
Results: Totally, 70 specimens were recorded as odontogenic cysts and 11 specimens were diagnosed as odontogenic tumors. The most frequent odontogenic cysts were dentigerous cysts [27.2%], followed by radicular cysts [18.6%] and odontogenic keratocysts [18.6%]. In addition, cysts were more frequent in male than female individuals. Ameloblastoma was the most frequent odontogenic tumor [64%]
Conclusion: Odontogenic cysts were in correlation with age, gender and location. These results showed that dentigerous cyst and odontogenic keratocyst were more frequent than other studies. More investigations should be performed to determine the frequency of odontogenic tumors in Iran
ABSTRACT
Oral squamous cell carcinoma [OSCC] is the most common type of oral cancer and dentists have a vital role in its prevention and early detection. The purpose of the present study was a comparative evaluation of knowledge between fifth and sixth year dental students and general dentists in Hamadan about to OSCC. This descriptive cross-sectional study was carried out in Hamadan in 2009. Eighty general dentists and 70 dental students participated in the study and filled out our questionnaire. Data were analyzed via SPSS software, version 16, by t-test and Pierson co-efficient correlation. The mean knowledge score was 8.55 +/- 2.21 and 6.48 +/- 2.34 of 13 in students and dentists respectively which was significantly different [P< 0.001]. There was not a significant correlation between either age, gender, interval of last study about OSCC, the interest in participation in related seminars and self evaluation of students about OSCC, with their knowledge score but dentists' knowledge were declined by increase in age, time passed from graduation and the last time of their study about OSCC statistically. This study indicated that knowledge of dental students and general dentists about OSCC is not enough in Hamadan; also, there was a significant difference between them and it seems there needs to be a greater emphasis on various educational programs about this subject both before and after graduation
ABSTRACT
The purpose of this study was to compare the histopathologic reaction of four suturing materials: silk, polyvinylidene fluoride [PVDF], polyglycolic acid, and catgut in the oral mucosa of albino rabbits. The twenty-one male mature albino rabbits which were used in this study were randomly divided into three groups of seven each. Silk, PVDF, polyglycolic acid and catgut suture materials were tested in the oral mucosa of these animals. The animals were sacrificed 2, 4, and 7 days after suturing. Two pathologists evaluated the samples by determining the presence and level of inflammation, granulation tissue, and fibrosis formation. Data were statistically analyzed by Kruskal Wallis and Mann-Whitney U tests. Histological features of the samples showed that PVDF and plain catgut suture materials produced more fibrous tissue [favorable response] on the fourth day in comparison with silk suture [P=0.02]. Also, in the 7-day samples PVDF sutures produced the mildest inflammation when compared with the silk sutures [P=0.015]. According to the results of this study, it can be convey that PVDF suture materials created mild tissue reactions and can be a reasonable candidate for suturing oral tissues